NCT04298502Unknown不适用
The Molecular Mechanism of CMV-driven NKG2C+NK Cell Expansion in Human
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- CMV viremia
研究概览
简要总结
This is an observation study to investigate the molecular mechanism of NKG2C+NK cell expansion after HCMV infection
详细描述
According to the changes of molecular and gene expression in NK cells at different time points after infection, we want to find out the mechanism by which HCMV promotes the expansion of NKG2C + NK cells.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AML or MDS or CML or ALL undergoing haploidentical stem cells transplantation
- •No severe organ dysfunction or failure
- •Subjects must be capable of, and willing to provide written informed consent to participate in the study. Subjects unable to provide written informed consent by themselves may be consented through their legal representative.
排除标准
- •Participation in another industry-sponsored clinical study where treatment for CMV is already specified by the study protocol.
- •Patients received other adoptive immunotherapy such as donor lymphocyte infusion (DLI), Epstein-Barr virus (EBV)-specific T cells and so on.
结局指标
主要结局
CMV viremia
时间窗: 2 moths post-transplantation
CMV-DNA\>1.0x10\^3 cpies/mL
次要结局
未报告次要终点
研究者
Xiaojun Huang,MD
Head of Peking University Institute of Hematology
Peking University People's Hospital
研究点 (1)
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