Investigation of the Glycemic Index of Table Grape Varietals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Glycemic Index
研究概览
简要总结
Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.
详细描述
The study aims to investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals, compared to a standard amount of glucose. The study also aims to evaluate a new grape varietal, compared to other common table grapes, with regard to glycemic index and metabolic response related to inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •21-75 years of age
- •BMI range 20-35
排除标准
- •adults unable to consent, individuals who are not yet adults (children), pregnant women, and prisoners.
- •BMI of >35 or morbid obesity.
- •Diagnosed type 1 or 2 diabetes, fasting blood glucose of >125 mg/dl, or reported use of medications or supplements known to affect glucose metabolism (insulin, sulfonylureas, metformin, glucosidase inhibitors, thiazolidinedione, insulin sensitizers, GLP-1 mimetics).
- •Medications known to affect gastrointestinal motility (prokinetic agents such as reglan).
- •Renal, liver, pancreatic or cardiovascular disease, uncontrolled hypertension of > 160/90, inflammatory bowel disease, disorders of esophageal and gastrointestinal motility, previous gastric resection or restriction procedures, autoimmune or immunologic disorders, anemia, breastfeeding women
- •Food allergy to grapes, or inability to tolerate gluten (celiac disease).
- •Poor venous access.
- •Smoking, illicit drug use, consuming >7 alcoholic drinks per week.
- •Weight gain or loss of > 5 kg within the prior 6 months.
- •Unwillingness to adhere to study protocol.
研究组 & 干预措施
Table grapes
Common grape varietal to test glycemic response and compare to the glycemic response elicited by the Milano grape varietal.
干预措施: Table grapes (Other)
Grape juice
Used to test the glycemic response without a complex food matrix and compare to the glycemic response elicited by the Milano grape varietal.
干预措施: Grape juice (Other)
Milano grapes
Unique grape varietal to test glycemic response.
干预措施: Milano grapes (Other)
Glucose beverage
Used to test the glycemic response with a standardized glucose beverage and compare to the glycemic response elicited by the Milano grape varietal.
干预措施: Glucose beverage (Other)
结局指标
主要结局
Glycemic Index
时间窗: 3 hours
The post-prandial glucose and insulin responses in healthy individuals to glucose containing foods or beverages.
次要结局
未报告次要终点