Immune Response to HPV Vaccine Among HIV-1-infected Subjects in Brazil
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Presence of Anti-HPV antibody titers
研究概览
简要总结
Besides the specific response to vaccine antigens, the investigators will analyze the anti-HPV immune response in HIV-1-infected men in different strata of immune deficiency. The hypothesis will be tested by stratification by T CD4 + lymphocytes in an attempt to assess the range of the count with the highest possibility of vaccine response. Thus, knowledge of vaccine response in HIV-infected patients, indicate which patients would have greater potential for vaccine response in vivo.
详细描述
The study will be divided into three groups. Patients with HIV-1 infection will be subdivided into groups according to T CD4 + lymphocytes at the time of vaccination: Over 500 CD4 T cells count and bellow 500 CD4 T cells count. A healthy control group will be also studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men with age between 35 and 45 years of age.
排除标准
- •Current or previous infection with human papillomavirus (HPV)
结局指标
主要结局
Presence of Anti-HPV antibody titers
时间窗: 0, 30 and 180 days of vaccination anti-HPV
The anti-HPV titers will be compared from baseline to the date of sample collection
次要结局
未报告次要终点
研究者
Jorge Casseb
PI
University of Sao Paulo