Pharmacodynamic Profile of 'Blackadder' Blackcurrant Juice Effects Upon the Monoamine Axis in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 主要终点
- Change from baseline Monoamine Oxidase B - Activity
研究概览
简要总结
The current study uses a double-blind, placebo-controlled, randomised cross- over design to assess the pharmacodynamics of the platelet MAO-B inhibition, plasma prolactin levels and blood glucose levels after consumption of a single serve of 'Blackadder' blackcurrant juice.
详细描述
There is emerging evidence which supports health benefits of consuming blackcurrant fruit, including improvements to cognitive performance, modulation of blood flow, regulation of blood glucose and inhibition of enzymes underpinning normal cognitive function. Of particular relevance is our previous demonstration of inhibition of MAO-A and B after consumption of a New Zealand 'Blackadder' blackcurrant juice drink in man.
In an attempt to establish a "therapeutic window" on which future nutritional interventions can be based, the current study will assess the pharmacodynamics of MAO-B inhibition, plasma prolactin levels and venous blood glucose profile following consumption of the 'Blackadder' blackcurrant juice. The trial will utilise a 500mg dose of the 'Blackadder' juice (equivalent to ~100g of fresh fruit) which was shown to have MAO inhibitory effects in our previous report and effects will be measured in a cohort of healthy male adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18-35
- •Non- smoker
- •No history of metabolic disease
排除标准
- •Diagnosis of blood-borne disease
- •Diagnosed history of any psychiatric disorder
- •Aged under 18 or over 35 years
- •BMI above 30 kg/m2 or below 17 kg/m2,
- •Diagnosis of diabetes or current use of prescription or over-the-counter drugs
结局指标
主要结局
Change from baseline Monoamine Oxidase B - Activity
时间窗: 15, 30, 45 60, 100, 120, 150, 180 and 240 minutes and 24h post dose.
Platelet monamine oxidase- B activity as measured by the Invitrogen amplex red assay
Change from baseline peripheral prolactin levels
时间窗: 15, 30, 45 60, 100, 120, 150, 180 and 240 minutes and 24h post dose.
次要结局
- Change from baseline postprandial blood glucose(15, 30, 45 60, 100, 120, 150, 180 and 240 minutes and 24h post dose.)