Evaluation of Immune Signaling Networks in Healthy Human Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Numerical and functional changes of circulating immune cells over time in healthy individuals
研究概览
简要总结
The purpose of this study is to better understand whether and to what extent the activity of immune cells in blood varies over time under normal conditions as assessed in healthy subjects. Results of this study will provide the foundation for helping us evaluate changes in immune cell activities in response to surgery and drugs used in anesthesia. The overall purpose of our research is to understand immune health in the context of anesthesia and surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Good general health
排除标准
- •Recent cold or flu
- •Chronic use of medications affecting the immune system
- •Chronic illness
- •Smoking habit
- •History of drug abuse
- •Current recreational drug use
结局指标
主要结局
Numerical and functional changes of circulating immune cells over time in healthy individuals
时间窗: Day 1, Day 2, Day 7, Day 28
This is an exploratory study. Numerical and functional (phosphorylation of signaling molecules and transcription factors) behavior of all circulating immune cells will be captured. Blood specimens collected at referenced time points will be analyzed with mass cytometry.
次要结局
未报告次要终点
研究者
Martin Angst
Professor of Anesthesia
Stanford University