The effect of Curcumin, Nigella Sativa, and Curcumin-Nigella Sativa on cellular- molecular and clinical outcomes related to primary osteoporosis among postmenopausal women: A triple blind randomized controlled trial

Tabriz University of Medical Sciences0 个研究点目标入组 120 人开始时间: 待定最近更新: 2023年2月7日

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•Postmenopausal women aged 50 to 65 years
•Ability to self-care
•Resident of Tabriz city
•Menstrual cessation for at least 12 consecutive months
•Low bone density (T-score <-2.5) in lumbar spine or hip (total and femoral neck)
•No fracture history
•The ability to communicate verbally for answering questions

•T-score=-4 in lumbar spine or T-score=-3.5 in femoral neck bone
•Renal failure and diseases
•Bone disease other than osteoporosis
•The use of medications that affect bone metabolism, including intravenous bisphosphonate over the past 5 years, oral bisphosphonate use in the last 6 months, cumulative oral bisphosphonate use for more than 3 years, or more than 1 month between 6-12 months before the study, Use of parathyroid hormone analogues over the past 12 months or strontium, fluoride or cathepsin k inhibitor at any time, use of hormonal medications or corticosteroids during the study or within 3 months before (or more).
•Chronic liver disease
•Other systemic diseases, such as diabetes, gastrointestinal disorders, and endocrine disorders
•Mental illness, as reported by the woman
•The malignancy, as reported by the woman
•Taking anti-coagulants, and coagulation disorders
•Stomach ulcers and gallstones
•The levels of 25-hydroxyvitamin D less than 20ng/ ml
•Current Hypercalcemia or hypocalcemia

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