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临床试验/CTRI/2025/06/089871
CTRI/2025/06/089871尚未招募不适用

Comparative Analysis of mirror therapy and Modified Constrained Induced Movement Therapy (mCIMT) on upper limb function and brain recognition in children with spastic cerebral palsy.

Anamika1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年11月7日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
upper limb coordination test, muscle tone, coginition test, upper limb functional test

研究概览

简要总结

Cerebral palsy (CP) is a group of permanent movement and posture disorders caused by non-progressive brain disturbances in fetal or infant development . It results from damage to the developing brain, often before or during birth, and manifests in various forms, including spasticity (muscle stiffness), dyskinesia (involuntary movements), and ataxia (poor coordination). CP can also lead to cognitive, communication, and behavioral challenges. While the severity varies among individuals, early intervention and therapy improve quality of life.CP is commonly associated with sensory, perceptual, and musculoskeletal issues, epilepsy, and secondary complications. Its prevalence is approximately 2.08 per 1,000 live births in Europe, with a significantly higher incidence in low-birthweight infants . Prematurity and low birth weight are major risk factors, although many cases occur in full-term infants without known causes .Both genetic and environmental factors contribute to CP. While genetic predisposition can lead to brain abnormalities, environmental influences such as prenatal infections, birth complications, and postnatal brain injuries also play critical roles. The interplay of these factors shapes the condition’s development .Despite being non-progressive, CP symptoms can evolve over time. The condition can arise at different stages—prenatal, perinatal, or postnatal—when the brain is highly susceptible to damage. Early detection and rehabilitation are essential for optimizing motor function and overall development .Treatment focuses on therapy to enhance mobility and function. Mirror therapy, which tricks the brain into perceiving movement in an impaired limb through a mirror reflection, is effective for hand and arm rehabilitation. Research is ongoing to explore its potential for other body parts .Constraint-Induced Movement Therapy (CIMT) is another rehabilitation technique that encourages the use of an affected limb by restricting the stronger one. A modified version (mCIMT) helps individuals with developmental disregard regain function through structured exercises, improving motor control and brain adaptability.Advances in neuroscience, particularly in brain recognition techniques, have led to breakthroughs in understanding neurological function and dysfunction. Research in this field has facilitated the development of innovative therapies, brain-computer interfaces, and AI-driven neurological interventions .Although CP remains a lifelong condition, continued advancements in therapy and rehabilitation offer promising improvements in mobility and overall quality of life.

Null Hypothesis

H01–There will not be  significant effect of mirror therapy on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone on spastic cerebral palsy.

H02 –– There will not be  significant effect of mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

H03 - There will not be  significant effect of Mirror therapy and mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

Alternate Hypothesis

H1 -There will be significant effect of mirror therapy on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy.

H2 – There will  be  significant effect of mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

H3 - There will be  significant effect of Mirror therapy and mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy.

Null Hypothesis

H01–There will not be  significant effect of mirror therapy on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone on spastic cerebral palsy.

H02 –– There will not be  significant effect of mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

H03 - There will not be  significant effect of Mirror therapy and mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

Alternate Hypothesis

H1 -There will be significant effect of mirror therapy on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy.

H2 – There will  be  significant effect of mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy

H3 - There will be  significant effect of Mirror therapy and mCIMT on coordinate movement both  hands , coordination in the upper limb extremities, Visual motor control and Muscle tone  on spastic cerebral palsy.

研究设计

研究类型
Interventional
分配方式
Random Number Table
盲法
Participant Blinded

入排标准

年龄范围
8.00 Day(s) 至 16.00 Day(s)(—)
性别
All

入选标准

  • 1.Diagnoses with spastic hemiplegic CP 2.Aged 8 to 16 years old 3.Able to follow instructions and complete testing 4.To sit without supervision, cognitive and verbal abilities (attention, working memory, and concentration) 5.Spasticity grade 1 or 1+ based on the Modified Ashworth Scale 6.Were not having incurable vision or hearing problems.

排除标准

  • 1.Diagnosed with mental retardation 2.Botulinum neurotoxin A injections in the previous 3.6 months or planned within the following 6 months; 4.Orthopedic surgery in the previous 12 months or planned within the study period; and 5.Orthopedic surgery or botulinum neurotoxin A injection in the involved upper limb during the past 6 months 6.Congenital deformity of upper limb 7.Previous surgery or pain in upper limb, vision problem, epilepsy, heart and respiratory problem.
  • 8.Previous surgery or pain in the upper limbs, vision problems, epilepsy, heart, and respiratory problems 9.Any other musculoskeletal problems that prevent the participants from doing resistance training.

结局指标

主要结局

upper limb coordination test, muscle tone, coginition test, upper limb functional test

时间窗: assessmet and intervention from 1 week to 6 week.

次要结局

未报告次要终点

研究者

发起方
Anamika
申办方类型
Private medical college

研究点 (1)

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