NCT06449729已完成不适用
Endocrine Determinants of Renal Function in Patients With Hypoparathyroidism on Conventional Treatment: a Cross-sectional Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- The rate of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism
研究概览
简要总结
Endocrine determinants of renal function in patients with hypoparathyroidism on conventional treatment: a cross-sectional study (ENDORSE)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years
- •diagnosis of chronic (≥ 1 year) post-surgical and autoimmune hypoparathyroidism, as established with undetectable or insufficient PTH concentration in relation to the presence of hypocalcemia
- •patients being treated with calcitriol or alfacalcidiol
- •patients able to sign the written informed consent
排除标准
- •pregnancy
- •severe renal failure requiring dialysis treatment
- •macroproteinuria
- •use of antihypertensive drugs such as thiazides, ACE inhibitors, sartans, beta and alpha blockers, and antialdosterone drugs
- •pazients affected by diabetes mellitus- insulin-treated
结局指标
主要结局
The rate of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism
时间窗: 12 months
Evaluation of the prevalence of renal failure and altered PTH-related renal active hormonal axis in patients with hypoparathyroidism (hypoPTH) in conventional treatment with calcium and vitamin D
次要结局
未报告次要终点
研究者
Andrea Giustina
Prorector and Head of Endocrinology
IRCCS San Raffaele
研究点 (1)
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