The efficacy of L-PRF and L-PRP in post extraction sockets of endodontically treated and devitalized teeth- a randomized control trial
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Post-operative pain will be assessed in groups A and B using the Visual Analog Scale.
研究概览
简要总结
Aim of the study:
To assess the efficacy of L-PRF and L-PRP in post extraction sockets of endodontically treated and devitalized teeth
Objective of the study:
1. To assess pain using Visual Analog Scale (VAS)
2. To assess bone levels using CBCT
3. To assess wound healing using Inflammatory, Proliferative and Remodelling Scale (IPR)
Describe how the study will be done in a step-wise chronological sequence:
Surgical procedures
Patients reporting to the department of Oral and Maxillofacial surgery OPD and who fit the into the inclusion criteria will be selected for the study. Detailed case history with informed written consent will be obtained from patients. Patients will be divided into Group A and Group B using lottery method. Nerve block will be given according to the tooth to be extracted and forceps are chosen. Once the tooth is extracted, curettage of the socket is done with thorough saline irrigation.
GROUP A
PRP clot is placed in the socket and covered with AbGel.The socket is then sutured with 3-0 silk suture. Post-operative CBCT will be taken immediately after extraction.Post-operative medications will be prescribed. Patient will be recalled after 8 weeks for follow up and CBCT.
GROUP-B
PRF clot is placed in the socket and covered with AbGel.The socket is then sutured with 3-0 silk suture.Post-operative CBCT will be taken immediately after extraction. Post-operative medications will be prescribed. Patient will be recalled after 8 weeks for follow up and CBCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Day(s) 至 45.00 Day(s)（—）
- 性别
- All
入选标准
- •1.Teeth that are Root canal treated and indicated for extraction
- •Root pieces that are indicated for extraction
- •Patients who are willing for blood sample collection for processing L-PRF and L-PRP.
排除标准
- •Ankylosed teeth
- •Teeth with periapical pathology or lesions
- •Any pre-malignant or malignant lesions
- •Patients with any blood dyscrasias.
结局指标
主要结局
Post-operative pain will be assessed in groups A and B using the Visual Analog Scale.
时间窗: 0 8weeks
Post-operative wound healing groups A and B will be assessed using Landry’s and modified Landry’s wound healing index.
时间窗: 0 8weeks
Post-operative bone regeneration levels will be assessed in groups A and B by CBCT.
时间窗: 0 8weeks
次要结局
- pain(0 5days)
研究者
Dr Vrinda Rajagopal
Dr DY Patil dental college and hospital, Pimpri, Pune