NCT00549614已完成不适用
Effect of 4 Weeks Treatment With Acipimox on Left Ventricular Function, Work Capacity, Insulin Sensitivity and Substrate Metabolism in Patients With Chronic Heart Failure
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- left ventricular ejection Fraction
研究概览
简要总结
The primary objective of this study is to evaluate whether metabolic modulation improves left ventricular function, work capacity, insulin sensitivity and modifies substrate metabolism in chronic heart failure
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •NYHA-class II-III.
排除标准
- •pregnancy
- •severe renal failure
- •new brady- or tachyArrhythmia
- •Severe stenotic valvular disease
- •myocardial infarction within last 6 weeks
- •insulin treated diabetes mellitus
- •peptic ulcer
- •pregnancy or lactating women
- •allergy towards tested medicine
研究组 & 干预措施
1
Experimental
干预措施: acipimox (Drug)
2
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
left ventricular ejection Fraction
时间窗: 4 weeks
exercise capacity
时间窗: 4 weeks
muscular metabolism
时间窗: 4 weeks
次要结局
- regional left ventricular function(4 weeks)
- insulin resistance(4 weeks)
- full body metabolism(4 weeks)
研究者
研究点 (1)
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