Association Between SLC25A48 Expression and Chronic Obstructive Pulmonary Disease Progression
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
- 试验地点
- 2
- 主要终点
- expression of SLC25A48
研究概览
简要总结
This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation with inflammatory markers and choline metabolic byproducts.
详细描述
Background:
Chronic obstructive pulmonary disease is the third leading cause of death worldwide, characterized by airflow limitation, alveolar damage, and chronic systemic inflammation. These features are closely associated with malnutrition, muscle loss, and oxidative stress. Mitochondrial dysfunction plays a critical role in immune dysregulation, with peripheral blood mononuclear cells widely used in studies on inflammation and metabolism. Choline, essential for one-carbon metabolism and immune function, requires specific transporters to enter mitochondria. SLC25A48, a newly identified mitochondrial choline transporter, is linked to impaired choline uptake, elevated reactive oxygen species, and metabolic imbalance. However, its role in chronic obstructive pulmonary disease remains unclear.
Study Design:
This multicenter, prospective observational study
Methods:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines (case group)
- •healthy individuals without chronic diseases or major medical conditions
排除标准
- •diagnosed with neuromuscular diseases
- •experienced respiratory disease exacerbation requiring emergency care or hospitalization in the past three months
- •assessed by a physician to have severe malnutrition or a significantly low BMI
- •continuously taking folic acid supplements
- •willing to receive or have already received self-paid nutrition clinic services at this hospital
研究组 & 干预措施
Control group
healthy controls
Case group
Pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines
结局指标
主要结局
expression of SLC25A48
时间窗: one day
the expression level of SLC25A48 in mitochondria isolated from peripheral blood mononuclear cells
次要结局
未报告次要终点
研究者
Ke-Yun, Chao
Assistant Professor
Fu Jen Catholic University