Evaluation of the Effects of Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy in Individuals With Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- periodontal pocket depth
研究概览
简要总结
This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.
A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being systemically healthy
- •Not smoking
- •Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
- •Not being pregnant or lactating
- •Not having received periodontal treatment in the last 6 months
- •Having at least 20 teeth in the mouth
- •Being diagnosed with periodontitis by the investigator
- •Having a dietary inflammatory index >0
排除标准
- •Having a systemic disease
- •Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
- •Being pregnant or lactating
- •Having received periodontal treatment within the last 6 months
- •Having fewer than 20 teeth in the mouth
- •No periodontitis
研究组 & 干预措施
Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
干预措施: non surgical periodontal trearment (Other)
Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
干预措施: anti-inflammatory nutrition education (Other)
Q3-2: Only nonsurgical periodontal treatment
干预措施: non surgical periodontal trearment (Other)
Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
干预措施: non surgical periodontal trearment (Other)
Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
干预措施: anti-inflammatory nutrition education (Other)
Q4-2: Only nonsurgical periodontal treatment
干预措施: non surgical periodontal trearment (Other)
结局指标
主要结局
periodontal pocket depth
时间窗: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
It will be calculated by measuring the distance between the gingival margin and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Clinical attachment loss
时间窗: baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.
It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
次要结局
- interleukin (IL)-1β level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
- interleukin (IL)-10 level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
- tumor necrosis factor (TNF)-α level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
- serum total oxidant status (TOS) level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
- serum total antioxidant status (TAS) level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
- serum C-reactive protein (CRP) level(baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.)
研究者
Hatice Yemenoğlu
Doctor
Recep Tayyip Erdogan University Training and Research Hospital