KCT0009238尚未招募Unknown
The effect of early administration of PCSK9 inhibitor, alirocumab to acute ischemic stroke patients associated with atherosclerosis on the stroke prognosis and lipid profile, a single center study, registry based, pragmatic, prospective trial
适应症
相关药物
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •Non-cardioembolic Stroke
- •Acute Ischemic stroke within 7 days of symptom onset (confirmed by CT or MRI)
- •Age 19 and above
- •Significant stenosis associated with atherosclerosis in major intracranial / extracranial vessels.
- •National Institutes of Health Stroke Scale(NIHSS) score of 15 or less at admission
- •Patients with the capacity to consent for participation in the clinical trial.
排除标准
- •Presence of high-risk factors for cardioembolism
- •Risk of ischemic stroke due to thrombosis from other causes
- •Patients with hemorrhagic stroke, brain tumors, or brain abscesses
- •Patients unable to take statins or PCSK9 inhibitors
- •Pre-stroke mRS score of 3 or higher
- •Severe liver failure (liver enzyme > 3 times the upper normal limit) or renal failure (serum Creatinine > 2mg/dL or estimated glomerular filtration rate < 30 mL/min/1.73m2)
- •Anemia (hemoglobin < 8mg/dL) or thrombocytopenia (platelet count < 100K)
- •Uncontrolled diabetes not managed by medication or insulin
- •Pregnant or breastfeeding patients
- •Patients already receiving PCSK-9 inhibitors
- •Patients deemed inappropriate for participation in the clinical trial by the investigator for other reasons.
研究者
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