Randomized, Active-Control Study to Determine the Effect of Mindfulness-Based Stress Reduction on Sympathetic Activity and Arterial Stiffness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Muscle Sympathetic Nerve Activity
研究概览
简要总结
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness. The investigator's central hypothesis is that MBSR will reduce sympathetic activity and arterial stiffness.
详细描述
This study will recruit male and female subjects with elevated blood pressure who will participate in a randomized, active control study to examine the impact of mindfulness-based stress reduction (MBSR) on blood pressure, muscle sympathetic nerve activity and arterial stiffness. The study will utilize established techniques for assessing blood pressure patterns (24-hour ambulatory monitoring), peripheral sympathetic activity (microneurography) and vascular stiffness (applanation tonometry) in humans. This study includes a stress management education class for the active control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Seated systolic blood pressure >119 mmHg and/or diastolic blood pressure >79 mmHg
- •Body mass index <30 kg/m2
排除标准
- •Pregnant women
- •History of autonomic dysfunction
- •Cardiovascular medication
研究组 & 干预措施
Mindfulness-Based Stress Reduction
An 8-week program specifically designed to improve mindfulness and to reduce stress.
干预措施: Stress Management (Behavioral)
Stress Management Education
An 8-week program specifically designed to provide education about stress responses in humans, and as an active control for Mindfulness-Based Stress Reduction studies.
干预措施: Stress Management (Behavioral)
结局指标
主要结局
Muscle Sympathetic Nerve Activity
时间窗: Data reported is the change in the mean value from before to after the 8 week intervention (i.e. pre to post).
Direct recordings of muscle sympathetic nerve activity from the peroneal nerve using microneurography. Sympathetic bursts that were at least three times higher than baseline noise were evaluated by a trained investigator and quantified as bursts per minute. The investigator was blinded to the condition and whether the data was pre or post until after all data was collected and analyzed.
次要结局
- Arterial Stiffness(Data reported is the change in the mean value from before to after the 8 week intervention (i.e. pre to post).)