An Exploratory Clinical Study to Evaluate the Safety, Tolerability and Biodistribution Characteristics of 177 Lu FAP VG11 Injection in Patients With Advanced Solid Tumours

Shandong Cancer Hospital and Institute1 个研究点分布在 1 个国家目标入组 7 人开始时间: 2026年6月17日最近更新: 2026年9月14日

适应症

干预措施

试验速览

阶段: 1 期
状态: 招募中
发起方
入组人数: 7
试验地点: 1
主要终点: Dose-Limiting Toxicities (DLT)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is an exploratory clinical study evaluating the safety, tolerability and biodistribution characteristics of 177Lu-FAP-VG11 injection in patients with FAP-positive advanced solid tumours.

详细描述

This is an exploratory, single-arm, dose-escalation, open-label early Phase I clinical study to evaluate the safety, tolerability, dosimetry and preliminary efficacy of 177Lu-FAP-VG11 injection in FAP-positive patients with advanced solid tumors.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Patients with advanced solid tumors who have failed standard therapy or for whom no standard therapy is available.
•Patients whose tumors are assessed as FAP-positive (high FAP expression with SUVmax uptake above liver background) by FAP-targeted diagnostic PET/CT imaging.
•In the investigator's judgment, no other treatment option with curative or life-prolonging potential is available.
•Male or non-pregnant, non-lactating females, aged ≥18 years.
•Eastern Cooperative Oncology Group (ECOG) performance status score ≤
•Life expectancy >6 months.
•Female patients: Women of childbearing potential must agree to use highly effective contraceptive methods from screening until 6 months after the last dose of study drug.
•Male patients: Subjects must use a condom during sexual intercourse during the study and for 14 weeks after the last study treatment to prevent partner pregnancy and to avoid transmission of the study drug via semen; in addition, subjects should refrain from sperm donation during treatment and for 6 months after the last study drug administration.
•Subjects must provide written informed consent voluntarily before participation in the trial.
•Willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures.

排除标准

•Clinically symptomatic central nervous system metastases or meningeal metastases, or other evidence that the patient's central nervous system or meningeal metastases are not controlled, and deemed unsuitable for enrollment by the investigator.
•Major organ surgery (excluding needle biopsy) or significant trauma within 4 weeks prior to the first use of study drug, or need for elective surgery during the study period.
•History of immunodeficiency, including positive HIV test, or other acquired or congenital immunodeficiency diseases, or history of organ transplantation, or severe autoimmune disease history deemed unsuitable for enrollment by the investigator; or allogeneic organ transplantation requiring immunosuppressive therapy.
•Receipt of systemic or local radioisotope therapy within 3 months prior to the first dose.
•Receipt of other investigational drugs not yet marketed within 4 weeks prior to the first use of study drug, or within five half-lives of the other investigational drug.
•Definitive history of neurological or psychiatric disorders, including epilepsy or dementia.
•Pregnancy or lactation, or unwillingness to use adequate contraceptive methods.
•Any severe concomitant disease that, in the investigator's opinion, would make the patient's participation in the study inadvisable or could affect compliance with the protoco.

研究组 & 干预措施

177Lu-FAP-VG11 injection treatment

Experimental

Patients will be treated with 177Lu-FAP-VG11 Injection

干预措施: 177Lu-FAP-VG11 (Drug)

结局指标

主要结局

Dose-Limiting Toxicities (DLT)

时间窗: Through study completion, assessed up to 2 years

Maximum Tolerate dose (MTD)

时间窗: Through study completion, assessed up to 2 years

Adverse Events