An adipocyte-driven mechanism for weight regain after weight loss: the yo-yo effect - ADIPOSTRESS

niversiteit Maastricht0 个研究点目标入组 58 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Subjects using prescription medication, or suffering from diseases or conditions that might influence the outcome of the study: this concerns diseases/medication that influence body weight regulation (malabsorption, untreated hypo/hyperthyroidism, eating disorders, systemic use of steroids, etc.) and obesity-related cardiovascular risk factors (heart disease, systolic and diastolic blood pressures > 160/100 mmHg, blood glucose > 6.1 mmol L-1, blood cholesterol > 7 mmol L-1, blood triglycerides > 3 mmol L-1), marked alcohol consumption > 21 alcoholic units week-1 (male), or >14 alcoholic units week-1 (female), planned major changes in physical activity during the study to an extent that might interfere with the study outcome, as judged by the investigator; blood donation within the past 2 months prior to the study; weight change of >3 kg within 2 months prior to the study; psychiatric disease (based on medical history only); pregnant or lactating women, or women planning to become pregnant within the next 12 months; surgically treated obesity; participation in other clinical studies within the last 3 months; drug abuse (based on clinical judgment); unable to give informed consent; unable to engage in a low-calorie diet; following a special diet (e.g. Atkins).

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