A Retrospective Comparison Of The Effects Of Low-Flow And High-Flow Anesthesia On Hemodynamics, Neutrophil-To-Lymphocyte Ratio, And Postoperative Outcomes In Tympanoplasty And Myringoplasty Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Postoperative neutrophil-to-lymphocyte ratio (NLR)
研究概览
简要总结
This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between [September 1, 2022] and [April 1, 2023]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.
详细描述
This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged between 18 and 75 years
- •American Society of Anesthesiologists (ASA) physical status classification I to III
- •Body Mass Index (BMI) between 18.5 and 29.9 kg/m²
排除标准
- •Age below 18 or above 75 years
- •Incomplete or missing clinical data
- •BMI less than 18.5 kg/m² or greater than 29.9 kg/m²
- •Presence of neurological disorders
- •History of renal or hepatic failure
结局指标
主要结局
Postoperative neutrophil-to-lymphocyte ratio (NLR)
时间窗: Within 1 hour postoperatively (Day 0)
The neutrophil-to-lymphocyte ratio measured from blood samples taken immediately after surgery to assess the systemic inflammatory response in patients undergoing tympanoplasty or myringoplasty with low-flow or high-flow anesthesia.
次要结局
未报告次要终点
研究者
Eda KAZANÇ ÖZDEN
Resident Doctor in Anesthesiology, Sponsor-Investigator
Karadeniz Technical University