NCT03841994已完成不适用
Association of Gut Microbiome With Neonatal Complications and Neurodevelopment in Preterm Infants
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
研究概览
简要总结
A prospective cohort study investigating the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
详细描述
The purpose of this study was to investigate the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 28 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preterm infants
- •born less than 28+0 weeks gestation
排除标准
- •Major congenital anomalies
结局指标
主要结局
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
时间窗: at 37~40 weeks of postmenstrual age
Comparison of gut microbiome with 16s RNA gene specific sequencing in stool, breast milk, gastric juice
次要结局
- Bayley scales of infant and toddler development, third edition(at 18~24 months of corrected age)
- Incidence of major morbidity(at 36~40 weeks of postmenstrual age)
- Brain MRI(at 37~40 weeks of postmenstrual age)
- Comparison of inflammation markers(with in 24 hours after birth, in 2 weeks, in 3~5 weeks, at 37~40 weeks of postmenstrual age)
- Comparison of short chain fatty acid at 4 period(with in 24 hours after birth, in 2 weeks, in 3~5 weeks, at 37~40 weeks of postmenstrual age)
研究者
Ee-Kyung Kim
Professor
Seoul National University Hospital
研究点 (1)
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