Comparison Between Effectiveness of Different Densities of Fractional Carbon Dioxide Laser in Treatment of Postburn Scar.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Clinical improvement Vancouver score
研究概览
简要总结
This study aims to compare effectiveness of different densities of carbon dioxide fractional laser in the treatment of postburn scar.
详细描述
The study included 25 Egyptian patients with burn scars recruited from the Out Patient Clinic, Dermatology Department, Cairo University. Each has three post burn scars, assigned to monthly fractional Carbon dioxide laser sessions with a total of 3 sessions. parameters are :
Lesion A or part A parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 900µm spacing (7.4% density).
Lesion B or part B parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 600µm spacing (12.6% density).
Lesion C or part C parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 300 µm spacing (25.6% density).
3 mm punch biopsy is taken before and one month after last session for assessment of collagen via (Masson's trichrome strain). In addition clinical evaluation is done via Vancouver & Patient and Observer Scar Assessment Scale .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
masked to the parameters of laser treatment in each lesion
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Burn scars of at least 1 year duration.
- •Patients with three separate lesions each of them about 2 to 5cm or patients with single lesion equal or more than 8 to 10cm.
排除标准
- •• Pregnancy.
- •Lactation.
- •Oral retinoid drugs within the past 6 months.
研究组 & 干预措施
Low density
Fractional carbon dioxide laser: Lesion A or part A parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 900µm spacing (7.4% density).
干预措施: Fractional Carbon Dioxide laser (Device)
Medium density
Fractional carbon dioxide laser : Lesion B or part B parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 600µm spacing (12.6% density).
干预措施: Fractional Carbon Dioxide laser (Device)
High density
Fractional carbon dioxide laser : Lesion C or part C parameters: 20 W, 800-1000μs dwell time, 2 to 3 stacks according to scar thickness, 300 µm spacing (25.6% density).
干预措施: Fractional Carbon Dioxide laser (Device)
结局指标
主要结局
Clinical improvement Vancouver score
时间窗: 1 month after last session
to compare the efficacy of different densities of fractional laser in treatment of post burn scars
次要结局
未报告次要终点
研究者
Suzan Shalaby
Principal investigator
Cairo University