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临床试验/NCT04979533
NCT04979533撤回不适用

Oxygen Insufflation: How High Flow, Low Pressure Oxygen Can Replace Jet Ventilation in Appropriate Surgical Airway Cases

University of Alabama at Birmingham0 个研究点开始时间: 2023年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
撤回
主要终点
High flow, low pressure oxygen can increase apneic oxygenation time during airway procedures

研究概览

简要总结

The purpose of this project is to evaluate the efficacy of oxygen insufflation (continuous oxygen flow) to keep oxygen saturation (oxygen levels measured with a pulse oximeter [finger device used in medicine]) at 90% or greater in adult patients undergoing microlaryngoscopy surgery.

详细描述

High flow, low pressure oxygen will be supplied in microlaryngoscopy airway surgery. These procedures are usually performed with jet ventilation (UAB) or intermittent apnea (surgery centers). Jet ventilation provides oxygenation with limited ventilation but come with high risks, such as barotrauma, pneumothorax, mucosa drying, and even death in the most severe cases. Intermittent apnea is a nuisance for the surgeon in that surgical time is often interrupted with having to place the endotracheal tube whenever the patient's oxygen saturation levels fall. The solution is oxygen insufflation, which will give extended oxygenation times for the surgeon to operate without the inherent risks associated with jet ventilation. During the procedure, oxygen tubing will be connected to the surgeon's laryngoscope instead of the jet ventilation tubing. Oxygen flows of 15 L/min will be administered through the laryngoscope to the posterior oropharynx. Endotracheal tube will be placed if oxygenation deemed insufficient due to oxygen saturations of <90%. Endotracheal tube will be intermittently placed to check and correct carbon dioxide levels.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Device Feasibility
盲法
None

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •adult patients undergoing microlaryngoscopy surgery without a tracheostomy

排除标准

  • •patients who have a tracheostomy

研究组 & 干预措施

Oxygen Insufflation

Experimental

Oxygen insufflation via oxygen tubing at 15 L/min

干预措施: Insufflator oxygen tubing (Device)

结局指标

主要结局

High flow, low pressure oxygen can increase apneic oxygenation time during airway procedures

时间窗: 30-60 minutes

15 liters per minute of oxygen will be administered to the posterior oropharynx.

次要结局

  • Degree of hypercapnia experienced by participants(30-60 minutes)
  • Participants That Maintain Adequate Oxygenation at 90% or Greater(30-60 minutes)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hollie Sanders

Certified Registered Nurse Anesthetist

University of Alabama at Birmingham

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