NCT01334762已完成不适用
Letrozole and CC Alone in an IUI Program in Women With Surgically Treated Minimal to Mild Endometriosis
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rate per cycle
研究概览
简要总结
To evaluate pregnancy rates with letrozole and CC alone in an IUI program for women with recently surgically treated minimal to mild endometriosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient with minimal-mild endometriosis recently treated by laparoscopy with a waiting period of 6 to 12 months following the procedure
- •No other infertility factors.
- •Normal serum basal hormone levels as well as documented ovulation
排除标准
- •Moderate or severe endometriosis
- •Dense adnexal and/or ovarian adhesions due to pelvic inflammatory disease or previous pelvic surgery
- •Age more than 36 years, BMI more than 30 kg/m2
- •women with a previous pregnancy
研究组 & 干预措施
Letrozole/IUI
Experimental
Patients received 5 mg letrozole daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.
干预措施: Letrozole/IUI (Drug)
CC/IUI
Active Comparator
Patients received 100 mg CC daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.
干预措施: CC/IUI (Drug)
结局指标
主要结局
Clinical pregnancy rate per cycle
时间窗: 6-7 weeks gestation
次要结局
- Miscarriage rate.(Up to 20 weeks gestation)
研究者
研究点 (1)
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