Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 152
- 试验地点
- 3
- 主要终点
- Response Bias
研究概览
简要总结
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-35 years
- •A first episode of a psychotic illness that began within the past three years
- •Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- •Taking 2nd generation antipsychotic medications
- •Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading
- •Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning
- •Sufficient fluency in English to comprehend testing procedures
- •Corrected vision of at least 20/30
排除标准
- •No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
- •No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
- •No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
- •For females: no current pregnancy
- •No sedatives or anxiolytics on the day of assessment
- •No medication change 3 weeks prior to enrollment
研究组 & 干预措施
Motivational Interview Intervention
This arm involves three 45-minute sessions on motivational interviewing targeting sensitivity to social reward.
干预措施: Motivational Interviewing (Behavioral)
Active Control Intervention
This arm involves three 45-minute sessions on didactic training on nutrition.
干预措施: Nutrition Didactic Training (Behavioral)
结局指标
主要结局
Response Bias
时间窗: 3 weeks
Response bias is defined as the likelihood of making one response, such as the frequently rewarded stimulus, more than the other response during the perceptual social reward learning task
the number of optimal response
时间窗: 3 weeks
The number of optimal response is defined as the number of responses choosing a stimuli with optimal outcomes (e.g., choosing a good over a neutral machine or choosing a neutral over a bad machine) during the inductive social reward learning task.
fMRI activation levels
时间窗: 3 weeks
fMRI activation is defined as beta weights from general linear model from key regions of interests including the ventromedial prefrontal cortex, dorsal anterior cingulate cortex and ventral striatum during the perceptual social reward learning task and the inductive social reward learning task.
次要结局
未报告次要终点
研究者
Junghee Lee
Associate Professor
University of Alabama at Birmingham