NCT03081429已完成不适用
A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Noncardiac Surgery
Beijing Tiantan Hospital2 个研究点 分布在 1 个国家目标入组 934 人开始时间: 2018年5月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 934
- 试验地点
- 2
- 主要终点
- The incidence of perioperative stroke
研究概览
简要总结
With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert stroke and postoperative cognitive outcomes. The investigators will perform a prospective cohort study. The aim of the study is to determine whether there is an association between perioperative covert stroke and postoperative cognitive outcomes in elderly patients undergoing noncardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Eligible patients were aged ≥60 years and scheduled for elective non-cardiac surgery with general anesthesia, with or without concomitant regional analgesia. They were expected to have surgery lasting at least 2 hours of anesthesia and to stay in the hospital at least 2 days thereafter.
排除标准
- •Patients have MRI contraindications, cannot complete the cognitive evaluation, undergo carotid artery surgery or refuse to sign informed consent will be excluded from the trial.
结局指标
主要结局
The incidence of perioperative stroke
时间窗: Postoperative 1-7 days
Stroke is diagnosed by MRI
次要结局
- The incidence of comorbidity.(30 days and 3 months after surgery)
- Recovery quality(1 day before surgery; and 7 days, 30 days, 3 months after surgery)
- The quality of life(1 day before surgery; and 7 days, 30 days, 3 months after surgery)
- Postoperative cognitive function(1 day before surgery; and 7 days, 3 months, 1 year after surgery)
- Depression state(1 day before surgery; and 7 days, 30 days, 3 months after surgery)
- Postoperative delirium(twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days)
研究者
Yuming Peng
Professor
Beijing Tiantan Hospital
研究点 (2)
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