Biomarkers Analysis of Mineralocortoid Receptor Activation in the Serum and Ocular Fluid of Patients With Choroidal Neovascularization
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 250
- 试验地点
- 4
- 主要终点
- biomarker analysis in blood and aqueous humor of patients with neovascularization and controls
研究概览
简要总结
The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
详细描述
Age-related macular degeneration (AMD) is the most frequent cause of blindness in industrialized countries. Multiple molecular pathways have been implicated in the pathogenesis of choroidal neovascularization (CNV). Currently, the treatment relies on neutralization of VEGF (Vascular Endothelial Growth Factor). However some patients have an incomplete response to anti-VEGF treatment. A recent study suggested the implication of the mineralocorticoid receptor pathway in the formation of CNV.
The study (of investigators) aim is to evaluate the concentation of metabolites of MR pathway in the blood and aqueous humor of patients with CNV and compared them with patients without CNV in order to increase our understanding of CNV pathogenesis and find potential biomarker of response to anti-VEGF treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of group 1:
- •Patients with type 1 choroidal neovascularization in a context of central serous chorioretinoathy or age related macular degeneration
- •Patients without intravitreal injection or last intravitreal injection > 3 months
- •Informed signed consent
- •Patients of group 2:
- •Patients without choroidal neovascularization
- •Patients with intraocular surgery (cataract or vitrectomy surgery)
- •Signed consent
排除标准
- •Myocardial infarction < 12 months
- •Chronic renal failure
- •Inflammatory disease
- •Infectious disease :HIV, viral hepatitis, tuberculosis
- •Type 1 or 2 Diabetes
- •Patients treated by mineralocorticoid antagonist treatment.
- •Type 2 or 3 choroidal neovascularization
- •Pregnant woman
结局指标
主要结局
biomarker analysis in blood and aqueous humor of patients with neovascularization and controls
时间窗: 24 months
Biomarker concentrations (pg/ml) will be evaluated with ELISA (Enzyme Linked ImmunoSorbent Assay).
次要结局
- biomarkers and treatment response(24 months)