2023-503660-17-00招募中3 期
J1I-MC-GZBN:A Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants who have Obesity or Overweight and Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 65
- 试验地点
- 8
- 主要终点
- Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
研究概览
简要总结
- To demonstrate that LY3437943 9 mg and/or 12 mg QW is superior to placebo for: change in the WOMAC Pain subscale AND change in bodyweight.
入排标准
- 年龄范围
- 18 years 至 65+ years（65+ Years, 18-64 Years）
- 接受健康志愿者
- 是
入选标准
- •Be overweight.
- •Have a history of 1 self-reported unsuccessful dietary effort to lose body weight.
- •Have knee pain prior to screening more than 12 weeks
排除标准
- •Have a change in body weight greater than 11 pounds
- •Prior joint replacement in the index knee
- •Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes.
结局指标
主要结局
Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Percent Change from Baseline in Body Weight
Percent Change from Baseline in Body Weight
次要结局
未报告次要终点
研究者
Lilly Clinical Trials information desk
Scientific
Eli Lilly & Co.
研究点 (8)
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