The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Analysis of the size distribution of nano-particles in exhaled breath condensate
研究概览
简要总结
Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of the particles to respiratory epithelial cells.
详细描述
This study investigates the following questions:
Does occupational exposure to nanoparticles influence permeation of such particles to respiratory airways? Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and their pulmonary functions.
Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and respiratory tract infections.
The study protocol includes the following steps:
Initial interview of the patient Measurement of nanoparticles in samples of exhaled breath condensate using NanoSight LM 20 Measurement of nanoparticles in induced sputum. And finally examination of the relationship between the measured parameters and the indices of pulmonary infection, and pulmonary function as measured by the pulmonary department of the TASMC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults over 20 years of age who visit Ichilov Hospital for medical complaints/inquiries regarding respiratory tract.
- •Study population is composed of people who are exposed to environmental particles form industrial sources.
- •Informed consent is requested from each subject.
排除标准
- •Unemployed individuals.
- •Individuals who are not working in industrial jobs, such as office workers and secretaries.
结局指标
主要结局
Analysis of the size distribution of nano-particles in exhaled breath condensate
时间窗: One year
Each subject will be examined once. The total time for collection of data is estimated as about one year.
次要结局
未报告次要终点