The Effects of High Intensity Exercise in Teens on Cognition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Profile of Mood States for Adolescents
研究概览
简要总结
This pilot study is a randomized control trial to test the effects of a 14-week home-based virtual, interactive high intensity interval training (HIIT) exercise intervention on cardiometabolic and cognitive outcomes in sedentary youth with overweight/obesity during adolescence. All participants (N=24) will complete screening via phone to determine eligibility. Eligible participants will be randomized to receive a) 14 weeks of a home-based HIIT intervention delivered via iPad or b) 14 weeks of a stretching intervention (control group). Each participant will undergo an in-lab pre- and post-test visit, where they will complete a fasting blood draw, a fitness test, and various cognitive and mental health measures.
详细描述
Rationale: Existing literature supports the premise that physical activity (PA) has beneficial effects on cognitive function in youth, but prior studies have limitations, such as cross-sectional designs with limited insights on the intensity or duration of PA or the biological underpinnings linking physical activity and mental health and cognitive function in adolescents. A limited number of studies (and none in the U.S.) have evaluated the effects of HIIT on cognitive processes in youth, particularly in youth with overweight/obesity whose age-related declines in PA puts them at increased risk for poor outcomes. This study is particularly timely during the current COVID-19 related public health crisis because our HIIT exercise intervention is time efficient, delivered remotely, and completed using space-efficient equipment in the home.
Intervention: Participants (youth ages 12-16 years with overweight/obesity) will be randomly assigned to complete a) 14 weeks of a home-based virtual, interactive HIIT intervention or b) 14 weeks of a stretching intervention (control group).
Objectives/Purpose: The overall goal is to improve cognitive and cardiometabolic outcomes in youth with overweight/obesity by implementing an at-home HIIT intervention. The aims of this study are: 1) to determine the feasibility, acceptability, and efficacy of HIIT in adolescents with overweight/obesity, 2) to examine the effectiveness of HIIT on cognitive and mental health outcomes, and 3) to examine the effectiveness of HIIT on cardiometabolic health.
Study Population: This study will consist of youth ages 12-16 years with overweight/obesity (BMI >=85th percentile) who do not meet current PA guidelines.
Study Methodology: This pilot study is a randomized control trial to test the effects of a 14-week home-based virtual, interactive high intensity interval training (HIIT) exercise intervention on cardiometabolic and cognitive outcomes in sedentary youth with overweight/obesity during adolescence. All participants (N=24) will complete screening via phone to determine eligibility. Eligible participants will be randomized to receive a) 14 weeks of a home-based HIIT intervention delivered via iPad (HIIT group) or b) 14 weeks of a stretching intervention (control group).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Typically developing youth.
- •Overweight/obese (BMI >= 85th percentile)
- •Does not meet current PA guidelines
- •Able and willing to complete HIIT exercise intervention.
- •Space for a stationary bike in the residence.
排除标准
- •Diagnoses of neurodevelopment or psychiatric disorders.
- •Diabetes, cardiovascular, pulmonary, or other significant medical problems.
- •Taking medications know to alter metabolism.
- •Allergy to metals.
- •Inability to participate in HIIT-based exercise or active involvement in sports/exercise programs.
结局指标
主要结局
Profile of Mood States for Adolescents
时间窗: 14 weeks
24-item scale with each ranging from 0 to 4; higher scores indicate a worse mood outcome
Self-Efficacy for Physical Activity Scale
时间窗: 14 weeks
5-item scale with each ranging from 1 to 5; higher scores indicating a better self-efficacy for physical activity outcome
Physical Activity Enjoyment Scale
时间窗: 14 weeks
18-item scale with each ranging from 1 to 7; higher scores indicate a better physical activity enjoyment outcome after reverse coding applicable items
Blood Pressure
时间窗: 14 weeks
systolic and diastolic blood pressure
Measures of intervention feasibility
时间窗: 14 weeks
percent of youth who complete an average of 70% of weekly minutes and percent of youth who attend 70% of exercise sessions
Measures of intervention efficacy
时间窗: 14 weeks
percent of sessions where youth achieve their target heart rate
Intervention Feasibility Measure
时间窗: 14 weeks
4-item scale with scores for each ranging from 1 to 5, higher scores indicate a better outcome for feasibility
Intervention Appropriateness Measure
时间窗: 14 weeks
4-item scale with scores for each ranging from 1 to 5; higher scores indicate a better outcome for appropriateness
Cognitive function measures
时间窗: 14 weeks
executive function, episodic and working memory tasks from NIH Toolbox, all age-adjusted T-scores
Glucose Sensitivity
时间窗: 14 weeks
glucose, insulin (to calculate Homeostatic Model Assessment for Insulin Resistance)
Intervention Acceptability Measure
时间窗: 14 weeks
4-item scale with scores for each ranging from 1 to 5; higher scores indicate a better outcome for acceptability
Vascular Endothelial-Derived Growth
时间窗: 14 weeks
vascular endothelial growth factor (VEGF) in pg/mL
Positive and Negative Affect Scale for Children
时间窗: 14 weeks
10-item positive and negative affect scale with scores for each ranging from 0 to 5; higher scores indicate a worse outcome for negative affect and better outcome for positive affect
State-Trait Anxiety Inventory for Children
时间窗: 14 weeks
20-item scale measuring acute and long-term anxiety, with a range from 20 to 80; higher scores indicate more anxiety
Perceived Stress Scale
时间窗: 14 weeks
10-item scale with each ranging from 0 to 4; higher scores indicate a worse stress outcome after reverse coding applicable items
Stress in Children Scale
时间窗: 14 weeks
21-item scale with each ranging from 0 to 4; higher scores indicate a worse stress outcome after reverse coding applicable items
Markers of inflammation
时间窗: 14 weeks
interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-a), all in pg/mL
Cardiorespiratory Fitness
时间窗: 14 weeks
maximal oxygen consumption (VO2max)
Body proportion
时间窗: 14 weeks
waist-to-height ratio
Body composition
时间窗: 14 weeks
percent body fat
次要结局
未报告次要终点
研究者
Britni Ryan Belcher, PhD, MPH
Assistant Professor
University of Southern California