Identifying Biomarkers Related to Post-stroke Cognitive Impairment: A fNIRS Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Preliminary screening of brain function biomarkers for post-stroke cognitive impairment
研究概览
简要总结
This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.
详细描述
This was an initial screening and preliminary intervention study. Both healthy subject and stroke patients will be included in this study. Brain functional activation of each subject during the cognitive task (Stroop task, 1-back task and verbal fluency test) will be evaluated using functional near-infrared spectroscopy (fNIRS). Cognitive function related scale assessment included Mental State Examination Scale (MMSE), Montreal Cognitive Assessment (MoCA), drawing clock test (DCT), Shape trials test A.B (STT-A, STT-B), standardized digital modal test (SDMT), auditory verbal learning test-Huashan version (AVLT-H), and activity of daily living (ADL) scale will be used to evaluate the function of each patient. Biomarkers related to post-stroke cognitive impairment will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Stroke patients:
- •Diagnosis of stroke confirmed by neuroimaging (CT or MRI)
- •18-80 years old
- •Able to complete the cognitive task
- •Able to follow instructions to complete the trial
- •Patients who signed an informed consent form.
- •Healthy Subjects:
- •No abnormalities on cranial
- •18-80 years old
- •Able to complete cognitive task
- •Able to follow instructions to complete the trial
- •not taking medications.
- •Subjects who signed an informed consent form.
排除标准
- •Stroke patients:
- •Inability to tolerate the test due to organic diseases
- •Serious mental illness that prevents them from cooperating with or tolerating the trial
- •Pregnant or lactating women
- •Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction.
- •Healthy Subjects:
- •Inability to tolerate the test due to organic diseases
- •Serious mental illness that prevents them from cooperating with or tolerating the trial.
- •Pregnant or lactating women
- •Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction
结局指标
主要结局
Preliminary screening of brain function biomarkers for post-stroke cognitive impairment
时间窗: 1 day
Comparison of differences in brain activation \[HbO2 (mmol/L\*mm)\] between patients with post-stroke cognitive impairment and patients without post-stroke cognitive impairment or healthy subjects
次要结局
未报告次要终点
研究者
Dingqun Bai
Director of rehabilitation Medicine
First Affiliated Hospital of Chongqing Medical University