Trichloroacetic Acid Versus Cantharone for the Treatment of Perenial Warts
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- Pain on treatment
研究概览
简要总结
Comparison of trichloroacetic acid versus cantharidine for the treatment of perenial warts.
详细描述
Warts are one of the most common sexually transmitted diseases. They are caused by the human papilloma virus (HPV) that causes cervical cancer. Warts can grow, obstruct labor, and spread. Patients presenting to the obgyn clinic with perenial warts were randomized to treatment with trichloroacetic acid (one of the many types of treatments) or to the treatment with cantharidine group. Cantharidine is a vesicant extracted from beetle bugs which painlessly causes a small blister to form and cures the patient from the HPV infection causing the wart . We compared cosmesis, scar formation, pain and number of treatments (visits) as well as effectiveness in both groups.
Objectives
- Determine if cantharone is more effective than trichloroacetic acid (TCA) for removal of warts
- Compare pain levels (pain during application) for each method
- Compare patient satisfaction for each method
- Compare scar formation and cosmesis for each method
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
盲法说明
Patients will be randomized to receive treatment with trichloroacetic acid or cantharidine.
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Warts on the perenial area
- •Less than 4mm across.
排除标准
- •Pregnancy
- •Less than 18 years old
- •Lesions larger than 4 millimeters across
- •Unclear diagnosis
- •Internal warts
- •Warts within 2 cm of mucosal areas
研究组 & 干预措施
Cantharidine group
Application of cantharidine to perenial warts
干预措施: Cantharidin (Drug)
trichloroacetic acid group
application of trichloroacetic acid to perenial warts
干预措施: Trichloroacetic Acid (Drug)
结局指标
主要结局
Pain on treatment
时间窗: at 30 minutes time point from application of treatment.
Comparison of pain when treatment is applied. The patient is asked on a scale of 0-5 (with 5 being extreme pain, 4 being severe pain, 3 being moderate, 2 being mild, 1 being slight and zero being no pain, how do you rate your pain.
次要结局
- Assessment of a patient's likelihood of using this method again as measured on a survey question(2 weeks from starting therapy)
- Presence of scarring or skin discoloration(2 weeks from starting therapy)
研究者
Maurice-Andre Recanati
Assistant Professor, Clinical Educator
Wayne State University