Blood Bioavailability of Two Different Doses of a β-alanine Supplement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Aminoacids in plasma
研究概览
简要总结
The purpose of this study is to To study the blood bioavailability of a sustained-release β-alanine granulated supplement of two different doses (10 g and 20 g).
详细描述
Subjects will consume 10 g of β-alanine one day by 4 ingestions of 2.5 g separated by 1 hour and 15 min. While on another day 20 g of β-alanine by 4 ingestions of 5 g separated by 1 hour and 15 minutes, with a washout period of 15 days between the two doses. Subsequently, the amino acid levels in blood will be analyzed after the product intake and during a period of 8 hours.
Each day of visit the paresthesias (moment of appearance, intensity and sensations) will be studied at different times.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men between 18 and 60 years old.
- •Cyclists with more than two years of cycling experience.
- •Bicycle training at least twice a week.
排除标准
- •Suffer a lasting injury that prevents you from training in the month prior to surgery.
- •Subjects with a chronic illness.
- •Having consumed in the three months prior to the start of the study any β-alanine supplement.
- •Making changes in diet or exercise during the study.
- •Inability to understand the informed consent form.
- •Consumption of other supplements that could alter the results of the study.
结局指标
主要结局
Aminoacids in plasma
时间窗: After the first intake of the product, samples will be taken at 15, 30, 45, 60 and 75 minutes. After the fourth and last product intake, samples will be taken at 15, 30, 45, 60, 75, 90, 120, 180 and 240 minutes.
The complete series of amino acids will be analyzed in plasma, after supplement intake, for 8 hours and at various times after product intakes. A bioavailability curve will be developed for each of these samples.
次要结局
- Paresthesia(After the first intake of the product, samples will be taken at 15, 30, 45, 60 and 75 minutes. After the fourth and last product intake, samples will be taken at 15, 30, 45, 60, 75, 90, 120, 180 and 240 minutes.)
- symptomatology - qualitative question(After the first intake of the product, samples will be taken at 15, 30, 45, 60 and 75 minutes. After the fourth and last product intake, samples will be taken at 15, 30, 45, 60, 75, 90, 120, 180 and 240 minutes.)
研究者
Francisco Javier López Román
Principal Investigator
Universidad Católica San Antonio de Murcia