Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- early and late cardiac injury due to CO poisoning description
研究概览
简要总结
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury.
This study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning
详细描述
This is a single-center retrospective study on health data. The methodology includes a collection of data on health and history data of patients treated by HBOT fo CO poisoning between 01/01/2015 and 31/12/2021 and carrying out a telephone interview of patients who have had early cardiovascular manifestations of CO poisoning.
One month between the start of theses interviews, an information letter on the study is sent by post, giving the possibility of opposing it.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015/01/01 to 2021/12/31
排除标准
- 未提供
结局指标
主要结局
early and late cardiac injury due to CO poisoning description
时间窗: enrollment (inclusion)
clinical manifestation, troponin elevation and/or ECG abnormality during acute CO poisoning description; then late cardiac manifestation and abnormality declared by patients who have had early cardiac abnormality (troponin elevation and/or ECG abnormalities)
次要结局
- relationship between cardiovascular risk factors or preexisting cardio vascular abnormality and cardiac injury(enrollment (inclusion))
- relationship between other possibly associated poisoning and cardiac injury(enrollment (inclusion))
- relationship between severity of neurological symptoms and cardiac injury(enrollment (inclusion))
- relationship between the source of CO poisoning and cardiac injury(enrollment (inclusion))
- relationship between context of poisoning (domestic, professionnal or intentional poisoning) and cardiac injury(enrollment (inclusion))