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临床试验/NCT02772913
NCT02772913Unknown不适用

Acute Mesenteric Ischemia in the Emergency Department: Incidence, Early Recognition and Risk Stratification From an Observational Multicenter Study

University of Genova1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2016年8月最近更新:
适应症

试验速览

阶段
不适用
入组人数
500
试验地点
1
主要终点
In-hospital mortality

研究概览

简要总结

Acute mesenteric ischemia is a life-threatening condition characterized by high mortality if unrecognized early. This multicenter retrospective observational study will review the emergency departments's (ED) notes of all patients discharged from hospital with a diagnosis of acute mesenteric ischemia in 2014-2015 comparing it with those admitted to the ED for abdominal pain in the same timeframe.

详细描述

Acute mesenteric ischemia is a condition characterized by non-specific presentation (typical clinical presentation is considered "abdominal pain out of proportion to examination") that may be under-recognized in the Emergency Department. Early identification and treatment is essential to improve outcome as mortality rate is attested around 80% if untreated within few hours from onset. The investigators aim to review the emergency department's clinical notes of patients discharged from hospital in 2014 and 2015 diagnosed with acute mesenteric ischemia. Furthermore the investigators will consider patients admitted for "abdominal pain" in the same time frame without acute mesenteric ischemia and we will compare presentation symptoms, medical history, medications, vitals, laboratory markers and imaging finding of the two groups. From this comparison, the investigators will be able to clarify the incidence among general population and among patients presenting acute abdominal pain. Finally, using multivariate analysis, the investigators may identify those variables predictive of acute mesenteric ischemia. This study will be held in three university hospitals and all data analyzed together.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • ICD-9 diagnosis of acute mesenteric ischemia in 2014 and 2015
  • Admitted to hospital after Emergency Department assessment

排除标准

  • post-traumatic or post-surgery related acute mesenteric ischemia
  • lack of assessment in the Emergency Department

结局指标

主要结局

In-hospital mortality

时间窗: 30 days from hospital admission

次要结局

  • in-hospital adverse outcome: cardiac arrest, ICU admission, septic shock, major bleeding.(30 days from hospital admission)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Stefano Sartini

Medical doctor, Consultant in Emergency Medicine

University of Genova

研究点 (1)

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