Antihypertensive Medications and the Risk of Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,129,062
- 主要终点
- Occurence of sepsis, including severe sepsis
研究概览
简要总结
The primary objective of this study was to assess whether there is an increased risk of sepsis with the use of telmisartan compared with other ARBs and with the other major antihypertensive classes, including ACEIs, beta-blockers, CCBs and thiazide diuretics. A secondary objective was to assess whether the use of ARBs and ACEIs, compared with the other three major antihypertensive classes and with untreated hypertension, is associated with an increased risk of sepsis. A third objective was to evaluate whether the use of telmisartan compared with other ARBs, ACEIs and other major antihypertensive classes is associated with an increased risk of worse outcomes due to sepsis, in particular acute kidney injury and death
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients, 18 years or older, with at least two-year follow-up in United Kingdom's general practice research database (GPRD), who had a diagnosis of or treatment for hypertension
排除标准
- •Sepsis, chronic renal failure or on dialysis in the two-year period prior to cohort entry
研究组 & 干预措施
Hypertensive patients
Hypertensive patients or patients treated with antihypertensive drugs with linked GPRD and hospital episodes statistics database (HES) data
干预措施: Telmisartan (Drug)
Hypertensive patients
Hypertensive patients or patients treated with antihypertensive drugs with linked GPRD and hospital episodes statistics database (HES) data
干预措施: Other angiotensin-receptor blockers (ARBs) (Drug)
Hypertensive patients
Hypertensive patients or patients treated with antihypertensive drugs with linked GPRD and hospital episodes statistics database (HES) data
干预措施: Angiotensin-converting enzyme inhibitors (ACEIs) (Drug)
Hypertensive patients
Hypertensive patients or patients treated with antihypertensive drugs with linked GPRD and hospital episodes statistics database (HES) data
干预措施: Other major antihypertensive medication classes (Drug)
结局指标
主要结局
Occurence of sepsis, including severe sepsis
时间窗: Up to 9 years and 5 months
Severe sepsis defined as cases that develop renal failure or die within 30 days
次要结局
未报告次要终点