NCT06917053招募中不适用
Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study
King's College Hospital NHS Trust1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2024年4月13日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Cortical mean transit time (mTT) measured in seconds
研究概览
简要总结
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Within 24 hours of ICU admission following traumatic injury
- •Received any blood products during initial resuscitation
- •Lactate > 2 mmol/l at any stage prior to study enrolment
排除标准
- •Known intolerance to Sonovue or any other ultrasound contrast agent
- •Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
- •Known CKD 4 or end stage renal failure
- •Pregnancy
结局指标
主要结局
Cortical mean transit time (mTT) measured in seconds
时间窗: Measured at enrollment, +24 hours and + 48 hours
Contrast enhanced ultrasound measure of renal cortical tissue blood flow
次要结局
- Urinary oxygen tension (pO2) across 24 hours study period measured in millimetres of mercury (mmHg)(Across 48 hour study period)
- Cortical perfusion index (PI) measured in arbitrary units(Measured at enrollment, +24 hours and + 48 hours)
- Cortical wash in rate (WiR) measured in arbitrary units(Measured at enrollment, +24 hours and + 48 hours)
研究者
研究点 (1)
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