Ovarian Reserve in Patients With Psoriasis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- to compare serum AMH levels between the two groups
研究概览
简要总结
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Autoimmune diseases including psoriasis are linked to premature ovarian reserve. This study aims to measure serum hormones including FSH,LH,E2,PRL and AMH (indicators of ovarian reserve) in women with and without psoriasis.
详细描述
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Almost 75% of patients are diagnosed before the age of 40. There is also increased evidence on autoimmune disease and their link to premature ovarian failure.Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients newly diagnosed with psoriasis and to compare them to healthy controls. Serum FSH,LH,E2,PRL and AMH will be measured on the 3rd day of the cycle.The serum hormone levels will be compared between women with psoriasis and women without psoriasis
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Reproductive age group women: 18-40 years
- •Women diagnosed with psoriasis (case group)
- •Women without psoriasis (control group)
排除标准
- •Women with PCOS (polycystic ovary syndrome)
- •history of ovarian surgery
- •Body mass index (BMI) over 30
- •Women with other autoimmune diseases including Hashitomo thyroiditis
- •Women with family history of premature ovarian insufficiency (POI)
- •Women with infertility
- •Psoriasis using systemic drugs including steroids and immunosuppressive therapy.
结局指标
主要结局
to compare serum AMH levels between the two groups
时间窗: 1 day
Serum AMH levels will be measured (using ELISA) and compared between the two groups
次要结局
未报告次要终点
研究者
Berna Aslan Cetin
Principle investigator
Kanuni Sultan Suleyman Training and Research Hospital