Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 3
- 主要终点
- Health-related quality of life
研究概览
简要总结
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Health-related quality of life (HRQL) is impaired in patients with IPF. Little is known about the properties of recently developed HRQL questionnaires and about the longitudinal changes in HRQL, including factors with an impact on HRQL. Comorbidities have an impact on patients with IPF, but reports differ in incidence and prevalence. The impact of comorbidities on HRQL and disease progression has only been studied sparsely. Also, the association between biomarkers and disease progression need to be examined further.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A clinical diagnosis of IPF
- •Signed informed consent
排除标准
- •Clinical, radiological or histological findings inconsistent with a diagnosis of IPF
- •Inability or unwillingness to adhere to the study
- •Active on lung transplantation list
结局指标
主要结局
Health-related quality of life
时间窗: Baseline, 2 weeks, 6 months, 12 months, 24 months, 36 months
Changes in King's Brief Interstitial Lung Disease questionnaire
Number and type of comorbidities
时间窗: Change/incidence at 6 months, 12 months, 24 months and 36 months
Incidence of new comorbidities after 6 months, 12 months, 24 months and 36 months
次要结局
- Lung function tests(Baseline, 6 months, 12 months, 24 months, 36 months)
- Disease progression(Baseline, 6 months, 12 months, 24 months, 36 months)
- 6-minute walk test(Baseline, 6 months, 12 months, 24 months, 36 months)
- Progression in serum/plasma biomarker levels(Baseline, 6 months, 12 months, 24 months, 36 months)
- Health-related quality of life(Baseline, 6 months, 12 months, 24 months, 36 months)