Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- "Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk"
研究概览
简要总结
Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective.
Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/
详细描述
Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk.
This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.
Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month.
- •The study is open to women who are breastfeeding or formula feeding.
排除标准
- •had twins or triples,
- •had any major complication of pregnancy(example,
- •gestational diabetes);
- •have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure;
- •use prescription or over-the-counter medicine or herbal drinks or pills.
- •History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse.
- •Severely claustrophobic.
- •Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter.
- •Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.
研究组 & 干预措施
Four weeks Postpartum Lactating
women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum.
干预措施: cross-sectional (Other)
Control Never Pregnant
women between 18 and 45 who have never been pregnant
干预措施: cross-sectional (Other)
结局指标
主要结局
"Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk"
时间窗: 5 years
Biomedical Research Study that will provide information on reducing maternal obesity.
次要结局
未报告次要终点
研究者
Enette Larson-Meyer
Phd, RD, FACSM
University of Wyoming