Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- Need for additional electrolyte supplementation
研究概览
简要总结
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous kidney replacement therapy with regional citrate anticoagulation.
详细描述
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous kidney replacement therapy with regional citrate anticoagulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any adult patient admitted to the intensive care unit with acute kidney injury requiring continuous kidney replacement therapy
排除标准
- •expected duration of continuous kidney replacement therapy less than 96 hours
- •prior continuous kidney replacement therapy before inclusion
- •a known hypersensitivity to citrate, acute liver failure or liver cirrhosis Child-Pugh C
- •persistent severe hemodynamic shock with decreased lactate clearance
- •a high likelihood of dying within the first 24h after initiation of CKRT
- •preexisting severe electrolyte disorders before CKRT initiation not attributable to Acute kidney injury
研究组 & 干预措施
Lo-RCA
Low concentrated citrate solution 18 mmol citrate per liter
干预措施: low concentrated citrate solution (18 mmol/L) (Device)
Hi-RCA
High concentrated citrate solution 136 mmol citrate per liter
干预措施: high concentrated citrate solution (136 mmol/L) (Device)
结局指标
主要结局
Need for additional electrolyte supplementation
时间窗: 96 hours
Need for additional electrolyte supplementation : magnesium, phosphate, potassium
次要结局
- Time course of serum electrolyte concentrations(96 hours)
- Incidence of electrolyte and acid-base disorders(96 hours)
研究者
Walter Verbrugghe
MD
University Hospital, Antwerp