NCT01569867已完成不适用
An Observational Study Investigating Genetic Influences on Statin Plasma Concentrations in Adult African American Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 501
- 试验地点
- 1
- 主要终点
- 24-hour area under the time-concentration curve of statin concentrations in plasma
研究概览
简要总结
This study intends to determine the effects of genetic polymorphisms on statin response and daily systemic exposure (24-hour area under the time-concentration curve) of statins in African-American patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •African-American patients taking a statin metabolized by CYP3A (e.g., atorvastatin, simvastatin, or lovastatin)
排除标准
- •Age less than 18 years
结局指标
主要结局
24-hour area under the time-concentration curve of statin concentrations in plasma
时间窗: 2 years
次要结局
- Incidence of statin-associated muscle symptoms (SAMS)(10 years)
研究者
Sakima Smith
Associate Professor
Ohio State University
研究点 (1)
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