The Effects of Preintubation Esmolol and and Dexmedotimidine on Ischmeia Modified Albumin Levels
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- ischemia modified albumine
研究概览
简要总结
This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective surgery under general anesthesia
排除标准
- •Patient refusal
- •Morbid obesity (BMI>30)
- •Advanced systemic disease
- •Hypoalbumiemia
- •beta-blocker usage
- •Anticipated difficult ventilation and/or intubation
研究组 & 干预措施
dexmedetomidine
0.5 mcg/kg dexmedetomidine in 20 ml normal saline will be infused in 5 minutes before intubation
干预措施: Dexmedetomidine (Drug)
Esmolol
0.5 mg/kg esmolol in 20 ml normal saline will be infused in 5 minutes before intubation
干预措施: Esmolol (Drug)
Placebo
20 ml normal saline infused in 5 minutes before intubation
干预措施: Placebo (Drug)
结局指标
主要结局
ischemia modified albumine
时间窗: 10 minutes after endotracheal intubation
ischemia modified albumine levels will be measured as a response to intubation
次要结局
未报告次要终点
研究者
Perihan Ekmekçi
Associate Professor
Ufuk University