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临床试验/NCT04433403
NCT04433403Unknown不适用

A Multicenter Clinical Study on the Detection of Pathogenic Microorganisms in Adult Severe Pneumonia Patients in Liaoning Province

Shengjing Hospital1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2020年7月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
300
试验地点
1
主要终点
Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province

研究概览

简要总结

This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province

详细描述

The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Meet the standard of severe pneumonia: Main standards: Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy.
  • Secondary standards:(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 < 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC < 4 × 109 / L); thrombocytopenia (< 10 × 109 / L); hypothermia (T < 36 ℃).

排除标准

  • refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples

结局指标

主要结局

Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province

时间窗: 2020.7-2023.12

Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hongyu Zhao

deputy director of emergency department

Shengjing Hospital

研究点 (1)

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