A Multicenter Clinical Study on the Detection of Pathogenic Microorganisms in Adult Severe Pneumonia Patients in Liaoning Province
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province
研究概览
简要总结
This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province
详细描述
The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet the standard of severe pneumonia: Main standards: Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy.
- •Secondary standards:(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 < 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC < 4 × 109 / L); thrombocytopenia (< 10 × 109 / L); hypothermia (T < 36 ℃).
排除标准
- •refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples
结局指标
主要结局
Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province
时间窗: 2020.7-2023.12
Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing
次要结局
未报告次要终点
研究者
Hongyu Zhao
deputy director of emergency department
Shengjing Hospital
