Boosting oxytocin after trauma: The effects of intranasal oxytocin administration on emotional and motivational brain processes in PTSD - The effect of oxytocin in PTSD

Academisch Medisch Centrum0 个研究点目标入组 83 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•* Age 18 * 65 years
•* Capable to read and comprehend the Dutch language
•* Eligibility for MRI (i.e. no metals, pacemakers or claustrophobia)
•* Exposed to a potentially traumatic event, according to PTSD A1 criterion in the DSM-IV (minimal 1 month ago), quantified as a score of 1 or higher on the Life Events Checklist (LEC).
•PTSD patients:
•* Current PTSD diagnosis
•* CAPS score * 45
•Traumatized healthy controls:
•* CAPS-score < 15

•* Any severe or chronic systemic disease
•* Current psychotic, bipolar, substance-related, severe personality disorder, or mental retardation
•* Current severe depressive disorder
•* Prominent current suicidal risk or homicidal ideation
•* Severe cognitive impairment or a history of organic mental disorder
•* History of neurological disorders (e.g., traumatic brain injury, seizure history)
•* Reports of ongoing traumatization (e.g., in case of partner violence as index adult trauma)
•* Evidence of clinically significant and unstable medical conditions in which OT administration is contra-indicative such as cardiovascular, gastro-intestinal, pulmonary, severe renal, endocrine or hematological disorders, glaucoma, history of epilepsy, or a stroke or myocardial infarction within the past year
•* Use of certain medication: prostaglandins, certain anti-migraine medications (ergot alkaloids), ß-adrenergic receptor-blocking agents, systemic glucocorticoids and psychopharmacological medication.
•* Sensitivity or allergy for OT or its components (e.g. methylhydroxybenzoate and propylhydroxybenzoate)
•* Female participants: pregnancy and breast feeding (NB. Female participants with childbearing potential must have a negative pregnancy test).
•Traumatized healthy controls only:
•* (lifetime history of) PTSD diagnosis, major depressive disorder.
•* Current DSM-IV axis 1 disorder

发起方