The Effect of Polychemotherapy on Endothelial Function Ans Vessel Age in Cancer Patients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Evaluation of blood pressure
研究概览
简要总结
In this research we investigate endothelial function in cancer patients who received platinum based chemotherapy.
详细描述
The goal of the study is to evaluate endothelial function in patients with platinum-based versus non-platinum-based chemotherapy.
Endothelial function was evaluated via Angioscan( the apparatus that evaluate the stiffness of vessels by pulse wave velocity) and serum levels of endothelial nitric oxide synthase (ENOS),endothelin1.
Patients with gastrointestinal, ovarian, bladder and brest cancer would be included.
Patients with malignancies were followed-up from 2 weeks to 3 month after start of chemotherapy, Medical records and hospital databases were searched for all the patients treated with different chemotherapy treatment for any kind of cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject has solid cancer
- •Subject is expected to start chemotherapy
排除标准
- •Pregnancy and lactation
- •Severe impaired kidney function
- •Severe hepatic impairment
- •Mental disease
- •Acute myocardial infarction 28 days ago or earlier
- •Acute Cerebrovascular Event 1 month ago or earlier
- •Rhythm disturbance that complicate pulse wave velocity evaluation
结局指标
主要结局
Evaluation of blood pressure
时间窗: Before start of chemotherapy (1 hour after including in the trial)
Both systolic and diastiolic blood pressure were measured in the office in the seated position, noninvasively.
Evaluation of flow-mediated vasodilation and pulse-wave velocity
时间窗: Before start of chemotherapy (1 hour after including in the trial)
Flow-mediated dilatation and pulse-wave velocity were measured via "Angioscan" apparatus in the seated position.The cuff inflation period of 5 min was initially decided to produce adequate hyperaemia to allow flow-mediated dilatation. The scanning period used in our trial was 1 minite before and 9 minutes after the cuff deflation.
Evaluation of concetration of ENOS and Big Endothelin in blood sampling
时间窗: Before start of chemotherapy (1 hour after including in the trial)
Blood was collected from the cubital vein to 10.0 ml/ 6.0 ml red top tubes (without clot activator). The sample was then separated by centrifugation. The serum was frozen to -20C.
次要结局
- Evaluation of blood pressure(In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection))
- Evaluation of concetration of ENOS and Big Endothelin of blood sampling(In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection))
- Evaluation of flow-mediated vasodilation and pulse-wave velocity(In range of 3 -12 weeks after start of chemotherapy (before next chepotherapy drug injection))