NCT03004066已完成不适用
Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patients
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- levels of Daptomycin in drainage fluid
研究概览
简要总结
10 patients with chronic heart failure receiving daptomycin therapy after implantation of a left ventricular heart assist system. Measurement of daptomycin levels in drainage fluids (mediastinal and pleural drainage systems) and in blood samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •written consent
- •heart assist device implantation
- •wound drainage
- •daptomycin therapy
排除标准
- •pregnancy
- •no written consent possible
- •absence of wound drainage
- •allergy to study medication
- •acute rhabdomyolysis
结局指标
主要结局
levels of Daptomycin in drainage fluid
时间窗: 4 days
Pharmacokinetics of Daptomycin in intensive care patients with wound drainage after surgery (LVAD implantation)
levels of Daptomycin in blood samples
时间窗: 4 days
Pharmacokinetics of Daptomycin in intensive care patients after surgery (LVAD implantation)
次要结局
- infections(14 days)
研究者
研究点 (1)
Loading locations...
相似试验
终止
不适用
Cerebrospinal Fluid Pharmacokinetics of DaptomycinMeningitisNCT01025271University of Pittsburgh2
已完成
3 期
Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass SurgeryLate Effects of SurgeryStaphylococcus AureusSurgical Site InfectionNCT00701636Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center30
进行中（未招募）
1 期
Daptomycin concentration in drainage fluid and blood samples of ICU patientsIntensive Care Patients after Surgery treated with Daptomycin and wound draingaeEUCTR2015-000125-36-DEniversity Hospital Tübingen9
终止
2 期
Safety and Efficacy of Doxycycline in Patients With Non-Ischemic CardiomyopathyNon-ischemic CardiomyopathySystolic Heart Failure (NYHA II-III)NCT01935622Virginia Commonwealth University10
Unknown
2 期
Daptomycin Pharmacokinetics in Continuous Veno-venous HemodiafiltrationBacteremiaNCT01171547University of Zurich15