NCT07152301已完成不适用
Inflammatory Activation, Epigenetic Signature and Morpho-structural Alteration in a Cohort of Patients With Chronic Heart Failure and Permanent Non-valvular Atrial Fibrillation: a Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 164
- 试验地点
- 1
- 主要终点
- inflammation and structural cardiac remodelling
研究概览
简要总结
the goal of this case-control cross-sectional study is assessing in a cohort of patients with CHF and permanent AF
- The serum levels of some candidate cytokine variables and their relationship with some selected metabolic variables and some echocardiographic variables.
- the expression degree of some selected miRNA with a pathogenetic relation to atrial fibrillation and the related cardiac remodelling.
- to analyze the correlation between selected miRNA and the selected cytokines.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
inflammation and structural cardiac remodelling
时间窗: From January 2020 to May 2022
in both arms of the study (AF + CHF and CHF no AF) a blood sample will be performed for the determination of serum values of inflammatory cytokines (CRP in mg/l; IL6 in pg/ml) and a transthoracic echocardiogram for the evaluation of the left atrial volume index in ml/m2 and the left atrial strain %
次要结局
- epigenetic alterations and cardiac remodelling(From January 2020 to May 2022)
- inflammation and epigenetic alterations(From January 2020 to May 2022)
研究者
Antonino Tuttolomondo
Prof.
University of Palermo
研究点 (1)
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