Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Behavioral: interference rate
研究概览
简要总结
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years or older (2/3 of the final sample will be ≥60years of age)
- •No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
- •Ability to give consent for study participation
- •who have access to a personal computer with internet
排除标准
- •• Pregnancy
- •Inability to use all ten fingers to type on a standard computer keyboard
- •Uncorrected vision, hindering perception of visual cues presented on a standard computer screen
- •Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;
- •Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing
- •Presence of neurological or psychiatric disorders
- •Presence of scalp injury or disease
- •Prior history of seizures
- •Prior intracranial surgery
- •Prior brain radiotherapy
- •Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
- •Metal in head or neck
- •Contraindications to MRI (such as severe claustrophobia, implanted medical devices)
研究组 & 干预措施
Active non-invasive brain stimulation during behavioral memory interference
Non-invasive brain stimulation with transcranial alternating current stimulation will be applied during a memory interference intervention.
干预措施: Transcranial alternating current stimulation (tACS) combined with behavioral intervention (Other)
Sham stimulation during behavioral memory interference
Inactive (sham) stimulation will be applied during a memory interference intervention.
干预措施: Inactive (sham) stimulation combined with behavioral intervention (Other)
结局指标
主要结局
Behavioral: interference rate
时间窗: before - after one single intervention (1 hour)
Change in performance precision of a previously learned sensorimotor skill
Neural: brain connectivity change
时间窗: before - after one single intervention (1 hour)
Change in EEG-derived markers of brain activation and connectivity
次要结局
- Behavioral: interference rate(before - after one single intervention (24 hour follow-up))
- Neural: brain connectivity change(before - after one single intervention (24 hour follow-up))
研究者
Kirstin-Friederike Heise
Assistant Professor-Faculty
Medical University of South Carolina