NCT01191827已完成不适用
fMRI Cholinergic Mechanisms in Schizophrenia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Neuronal Response During Sensory Gating
研究概览
简要总结
This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.
详细描述
This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of schizophrenia
- •age 18-60 yrs
排除标准
- •claustrophobia
- •weight > 250 lbs
- •metal in body other than dental fillings
结局指标
主要结局
Neuronal Response During Sensory Gating
时间窗: Immediate
Neuronal response (blood oxygenation level dependent functional magnetic resonance imaging signal, relative to the global mean) during sensory gating. Sensory gating is defined as the process of filtering out unnecessary environmental stimuli.
次要结局
未报告次要终点
研究者
研究点 (1)
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