Association of Constipation Inflammatory and Microbial Translocation Markers as Well as Markers of Microbial Translocation Including Endotoxin and Its Antibodies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Microbial Translocation Markers
研究概览
简要总结
Growing evidences showed that patients with chronic constipation accompanied with intestinal dysbiosis. Gut dysbiosis is a harbinger of chronic inflammation, yet the underlying basis is unclear. Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and is a source of systemic immune activation in CKD patients. The passage of microbial components from the gastrointestinal tract into the systemic circulation may be an important contributor to the chronic inflammatory process and subsequent atherosclerosis development. We plan to determine the association constipation with biomarkers of inflammation such monocyte activation and associated cytokines as well as markers of microbial translocation including endotoxin and its antibodies, intestinal barrier proteins of 200 hemodialysis patients.
详细描述
Study Design and Population
Patients and methods 2.1. Patient selection Two hundred hemodialysis patients are recruited. Functional constipation will be diagnosed according to the Rome IV criteria. Organic lesions of the abdominal cavity and the pelvic floor are excluded in all patients by endoscopic (sigmoidoscopy, colonoscopy, gastroduodenoscopy), radiologic and ultrasonographic evaluation.
This study will be carried out in accordance with the Declaration of Helsinki as revised in 2008. All patients will give written informed consent to participate in the study. All patients in the renal division of Tungs Taichung Metroharbour Hospital were prospectively and consecutively included. The inclusion criteria are
- Hemodialysis for more than 3 months
- Age older than 20 years old
The exclusion criteria are a history of chronic inflammatory disease, the presence of current infection, collagen vascular disease or immuno-modulatory or immuno-suppressive treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hemodialysis for more than 3 months and Age older than 20 years old
排除标准
- •he exclusion criteria are a history of chronic inflammatory disease, the presence of current infection, collagen vascular disease or immuno-modulatory or immuno-suppressive treatment.
结局指标
主要结局
Microbial Translocation Markers
时间窗: 1 years
Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and is a source of systemic immune activation in CKD patients. microbial translocation including endotoxin and its antibodies, intestinal barrier proteins
次要结局
未报告次要终点