Evaluation of Decision-Making Fatigue After Traumatic Brain Injury (EDIFY)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Feasibility of using COGED and Bandit computerized assessments in evaluating Decision-Making Fatigue after TBI
研究概览
简要总结
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
详细描述
This study aims to measure the effects of traumatic brain injury in the acute and subacute phases of recovery using these two noninvasive computerized assessments (COGED and bandit). All participants engaged in the study will participate in a total of three visits at Hennepin Healthcare Systems, Inc. (HHS). Each visit will consist of surveys and computerized assessments that will help researchers to understand the effects of decision-making on mental fatigue.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for TBI Participants:
- •Adults 18 years and older
- •Diagnosis of a mild to moderate TBI (GCS > 8 on admission)
- •Able to perform a computerized assessment
- •Willing to attend all scheduled appointments
- •Able to undergo the informed consent process
- •Inclusion Criteria for Healthy Participants:
- •Adults 18 years and older
- •Able to perform a computerized assessment
- •Willing to attend all scheduled appointments
- •Able to undergo the informed consent process
排除标准
- 未提供
研究组 & 干预措施
COGED
The COGED task consists of the classic N-back task of working memory-based decision making, followed by a valuation phase. The N-back phase of the task allows calculation of cognitive performance of a working memory task. During valuation, participants receive titrating offers of differing amounts of money to perform different difficulty levels of the N-back. The result is an effort discounting curve used to measure the individual effort cost. Effort discounting curves show the perceived cognitive effort required to complete each level of the task relative to another (typically the 1-back).
干预措施: COGED (Behavioral)
Restless Bandit
Participants are presented with three targets (decks of cards) on the screen, which they select with a mouse movement. Each of the three targets is associated with a hidden probability of reward, which drifts unpredictably and independently across trials. This encourages participants to "exploit" good options when they are available, but also occasionally to "explore "other targets, which could become better at any time. Eye Tracking is done at each visit while the participant completes the Restless Bandit tasks.
干预措施: Restless Bandit (Behavioral)
结局指标
主要结局
Feasibility of using COGED and Bandit computerized assessments in evaluating Decision-Making Fatigue after TBI
时间窗: 4 years
Feasibility will be calculated using the sum total number of patients who completed at least 80% of study procedures divided by the sum total number of patients, which is a proportion ranging from 0 to 1. We will then determine if that exceeds 0.5, with higher numbers indicating more feasible.
次要结局
- Acceptability of using COGED and Bandit computerized assessments in evaluating Decision-Making Fatigue after TBI(4 years)
