Cancer screening using liquid biopsy stem cell-based tests
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Identification of cancer & non-cancer subjects using biochemical fingerprints of
研究概览
简要总结
Aim: Cancer screening using liquid biopsy stem cell-based tests
Milestone to be achieved: To demonstrate the feasibility of stem cell-based tests for determination of cancer presence in a larger cohort.
Study Design: 12 ml of peripheral blood sample will be collected from all eligible subjects for the study.
Objectives:
1. 1. To assess the feasibility of Raman Spectroscopy as a screening tool for cancer detection
2. 2. To enrich circulating stem cells from peripheral blood of cancer and non-cancer subjects and determine expression patterns of various markers by droplet digital PCR (ddPCR) and quantitative PCR (qPCR).
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Non-cancer individuals:
- •18 years and above healthy individuals will be included in the study.
- •Individuals with no prior history of cancer will be included.
- •Cancer patients:
- •18 years and above cancer patients will be included in the study.
- •Cancer patients will be confirmed on histopathology irrespective of grade and stage.
排除标准
- •Age less than 18 years.
- •Verified biohazard samples will be excluded.
- •Cancer subjects who have received anticancer treatment within 7 days of sample collection
- •Subjects who have undergone surgery within previous 2 weeks of sample collection
- •Subject should not have got any blood transfusion or blood donation in the last 2 weeks.
- •Pregnant/ lactating females
- •Subjects who have received growth factors in past 2 weeks.
结局指标
主要结局
Identification of cancer & non-cancer subjects using biochemical fingerprints of
时间窗: Baseline
Raman Spectroscopy & expression patterns of ddPCR or qPCR
时间窗: Baseline
次要结局
未报告次要终点